人参皂苷Rb2致中国仓鼠肺细胞染色体畸变的作用

doi:10.3969/j.issn.1004-616x.2012.04.014

›› 2012, Vol. 24 ›› Issue (4): 298-301.doi: 10.3969/j.issn.1004-616x.2012.04.014

• 检测研究 • Previous Articles Next Articles

Effects of ginsenoside Rb2 on chromosome aberration in Chinese hamster lung cells

GAO Mei;CAO Chong;ZHU Chun-hua;QU Bao-en

(Institure of Pharmaceutical Industry，Shandong Provincial Key Laboratory of Chemical Drug，Jinan 250101，Shangdong, China)

Received:2012-02-20 Revised:2012-05-23 Online:2012-07-30 Published:2012-07-30
Contact: GAO Mei

Abstract

Abstract: OBJECTIVE: To explore the effects of ginsenoside Rb2 on chromosome aberration in Chinese hamster lung(CHL) cells. METHODS：We used the method of cell counting to determine the IC50 of ginsenoside Rb2 on CHL cells，then established the range of doses according to the IC50 and performed chromosome aberration. The results were based on the chromosome number and structural changes. RESULTS：Negative response was found at 6 h and 24 h after treatment with ginsenoside Rb2 and at 6 h after the addition of S9 mixture. CONCLUSION：The ginsenoside Rb2 did not induce chromosome aberration in CHL cells under our experimental conditions.

Key words: ginsenoside Rb2, Chinese hamster lung cells, chromosome aberration

GAO Mei;CAO Chong;ZHU Chun-hua;QU Bao-en. Effects of ginsenoside Rb2 on chromosome aberration in Chinese hamster lung cells[J]. , 2012, 24(4): 298-301.

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Effects of ginsenoside Rb2 on chromosome aberration in Chinese hamster lung cells

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